Colts vs Bills Preseason Picks and Predictions: Keenum Leads Buffalo to Start Preseason

The Indianapolis Colts and the Buffalo Bills open their respective preseason slates when they meet at Highmark Stadium this afternoon.

The Colts are looking to wipe the bad taste from their mouths of an embarrassing Week 18 loss to the Jaguars that cost them a playoff berth. The Bills won the AFC East last season but were ultimately dispatched in the divisional round in overtime by the Kansas City Chiefs in an instant classic. 

Which AFC playoff hopeful will start their preseason with a victory? Find out in our free NFL picks and predictions for Colts vs. Bills on Saturday, August 13.

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